Competing risks.

نویسندگان

  • Jason Fine
  • Bo Henry Lindqvist
چکیده

Consider a unit which can experience any one of k competing failure types, and suppose that for each unit we observe the time to failure, T , and the type of failure, C ∈ {1, 2, . . . , k}. The case of observing the pair (T, C) is termed “competing risks” in the statistical literature. After considering some examples we review basic notation and theory of competing risks. In particular we consider the latent failure time approach to competing risks in which the k risks are represented by potential failure times T1, . . . , Tk where only the smallest, T = minj Tj , is observed together with its index C = argminj Tj . In reliability studies, the marginal distributions of the Tj are often of primary interest, but are unfortunately non-identifiable in general. Additional, though non-testable, assumptions to obtain identifiability are considered, as are bounds for the marginal distributions given in terms of observable functions. The likelihood function of right censored competing risks data is given and its consequences for both parametric and non-parametric estimation are explained. Extensions of the classical theory of competing risks to more general Markov models and to repairable systems are briefly discussed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Parametric Estimation in a Recurrent Competing Risks Model

A resource-efficient approach to making inferences about the distributional properties of the failure times in a competing risks setting is presented. Efficiency is gained by observing recurrences of the compet- ing risks over a random monitoring period. The resulting model is called the recurrent competing risks model (RCRM) and is coupled with two repair strategies whenever the system fails. ...

متن کامل

Comparison of Random Survival Forests for Competing Risks and Regression Models in Determining Mortality Risk Factors in Breast Cancer Patients in Mahdieh Center, Hamedan, Iran

Introduction: Breast cancer is one of the most common cancers among women worldwide. Patients with cancer may die due to disease progression or other types of events. These different event types are called competing risks. This study aimed to determine the factors affecting the survival of patients with breast cancer using three different approaches: cause-specific hazards regression, subdistri...

متن کامل

Factors Affecting the Risk of Death in Patients with Rectal Cancer: An Analysis in the Presence of Competitive Risks

Background and Objectives: The incidence of rectal cancer is increasing in developing societies, especially in younger age groups. The aim of this study was to evaluate the factors affecting the survival of patients with rectal cancer in the presence of competing risks.   Methods: In this retrospective cohort study, the data of 121 patients with rectal cancer during 2001-2017 were studied. De...

متن کامل

Determining factors contributing to the five-year survival of children suffering from acute lymphoblastic leukemia based on tree survival model in the presence of competing risks

Abstract Background and objectives: Leukemia is one of the most prevalent cancers worldwide. The relapse of the disease mitigates patient survival time. The convenience of explaining the results obtained from analyzing tree models have encouraged doctors and paramedics to employ them in their research. The current study is an attempt to determine the five-year survival time and factors influen...

متن کامل

کاربرد مدل ریسک رقابتی در شناسایی عوامل موثر بر زمان بقای بیماران مبتلا به سرطان کولورکتال

Background and Objective: Colorectal cancer is the most common cancer of digestive system in Iran.The incidence of this cancer has increased in recent years.The aim of this study was to evaluate the survival rate and to define the prognostic factors in Iranian colorectal cancer patients using competing risk model. Materials and Methods: Data recorded from 1060 patients with colorectal cancer...

متن کامل

Cumulative incidence in competing risks data and competing risks regression analysis.

Competing risks occur commonly in medical research. For example, both treatment-related mortality and disease recurrence are important outcomes of interest and well-known competing risks in cancer research. In the analysis of competing risks data, methods of standard survival analysis such as the Kaplan-Meier method for estimation of cumulative incidence, the log-rank test for comparison of cum...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Lifetime data analysis

دوره 20 2  شماره 

صفحات  -

تاریخ انتشار 2014